We studied 42 women with normal cervix and 63 women with invasive cervical carcinoma to investigate the correlation between the prognostic variables of the cervical cancer(age, clinical stage, tumor size, depth of invasion, lymph node metastasis)
and
ras gene expression, analyzed using immunohistochemical staining with formalin fixed paraffin embedded tissues from January 1985 to Decemeber 1986. And we determined the prognostic significance by comparing the 5-year disease free survival rate
according to ras gene expression.
There was significant difference in ras nocogene expression between the normal cervix and the invasive cervical carcinoma(0%, 22.2%; p<0.02). And the ras gene expression was increased significantly according to clinical stage and lymph node
metastasis.
But the ras gene expression was not significantly associated with age, primary tumor size, and depth of invasion. And no significant difference in 5-year free survival rate y the ras gene expression in cervical carcinoma.
So these data suggest that the ras gene expression may be associated with the cervical tumorigenesis, but not useful as an independent prognostic factor of the cervical carcinoma.
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